Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.30 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844424 | 0.85 | CYP11B2 (0.35) | STK4RPS6KA3PLK1PLK3PLK2 | |
| SCHEMBL6844422 | 0.85 | STK4 (0.36) | STK4RPS6KA3PLK1PLK3PLK2 | |
| SCHEMBL7742264 | 0.84 | KCNA5 (0.34) | STK4RPS6KA3 | |
| SCHEMBL2347759 | 0.80 | PLK1 (0.51) | STK4PLK1PLK3PLK2 | |
| SCHEMBL2347754 | 0.80 | PLK1 (0.51) | STK4PLK1PLK3PLK2 | |
| SCHEMBL6840403 | 0.80 | STK4 (0.38) | STK4RPS6KA3PLK1PLK3PLK2 | |
| SCHEMBL6840522 | 0.77 | USP1 (0.35) | STK4RPS6KA3PIK3CA | |
| SCHEMBL6840386 | 0.75 | STK4 (0.34) | STK4RPS6KA3PLK1 | |
| SCHEMBL2032478 | 0.74 | PLK1 (0.54) | PLK1PLK3PLK2 | |
| SCHEMBL2032483 | 0.74 | PLK1 (0.54) | PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |