Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988281 | 0.90 | ROCK2 (0.61) | RAB9ANPC1BRAFROCK2ROCK1 | |
| SCHEMBL6845277 | 0.89 | ROCK2 (0.44) | RAB9ANPC1BRAFROCK2ROCK1 | |
| SCHEMBL987306 | 0.76 | ROCK2 (0.65) | RAB9ANPC1BRAFDEGS1ROCK2 | |
| SCHEMBL30192651 | 0.75 | ROCK2 (0.77) | RAB9ANPC1TRPV1ROCK2ROCK1 | |
| SCHEMBL6559116 | 0.75 | ROCK2 (0.64) | RAB9ANPC1BRAFROCK2ROCK1 | |
| SCHEMBL6845275 | 0.75 | ROCK2 (0.47) | RAB9ANPC1BRAFDEGS1TRPV1 | |
| SCHEMBL23844169 | 0.73 | LMNA (0.76) | RAB9ANPC1TRPV1ROCK2ROCK1 | |
| SCHEMBL19860113 | 0.72 | NPC1 (0.76) | RAB9ANPC1DEGS1TRPV1LMNA | |
| SCHEMBL4609178 | 0.71 | RAB9A (0.67) | RAB9ANPC1KDM4ELMNATP53 | |
| SCHEMBL4609954 | 0.71 | RAB9A (0.67) | RAB9ANPC1KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |