Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842637 | 0.91 | NR1H4 (0.61) | NR1H4MMP13HDAC3HDAC1HDAC2 | |
| SCHEMBL6843373 | 0.88 | LMNA (0.48) | NR1H4MMP13CYP3A4LMNAHTT | |
| SCHEMBL6843207 | 0.88 | NR1H4 (0.55) | NR1H4MMP13HDAC3HDAC1HDAC2 | |
| SCHEMBL6843326 | 0.88 | NR1H4 (0.55) | NR1H4MMP13SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL6843480 | 0.88 | NR1H4 (0.55) | NR1H4MMP13SMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL6843414 | 0.88 | NR1H4 (0.55) | NR1H4MMP13CYP3A4MAPK14LMNA | |
| SCHEMBL6845319 | 0.88 | NR1H4 (0.55) | NR1H4MMP13LMNAHDAC3HDAC1 | |
| SCHEMBL6843011 | 0.87 | NR1H4 (0.52) | NR1H4MAPK14HDAC3HDAC1HDAC2 | |
| SCHEMBL6195421 | 0.86 | NR1H4 (0.57) | NR1H4MMP13CYP3A4MAPK14LMNA | |
| SCHEMBL6842474 | 0.86 | NPC1 (0.54) | NR1H4MMP13SMN1; SMN2HDAC1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | MMP9, MMP8, MMP13 | NR1H4 1615/4885MMP13 3/4885CYP3A4 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.