Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845485 | 0.79 | BACE1 (0.46) | BACE1CTSD | |
| SCHEMBL2371270 | 0.68 | CYP11B2 (0.37) | BACE1KCNH2CTSDCYP11B2 | |
| SCHEMBL6845659 | 0.67 | BACE1 (0.53) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL2371594 | 0.62 | BACE1 (0.70) | BACE1KCNH2CTSD | |
| SCHEMBL2370674 | 0.62 | BACE1 (0.70) | BACE1KCNH2CTSD | |
| SCHEMBL6845347 | 0.60 | BACE1 (0.57) | BACE1KCNH2CTSD | |
| SCHEMBL10285710 | 0.60 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL7705408 | 0.58 | BACE1 (0.35) | BACE1KCNH2CTSD | |
| SCHEMBL5680280 | 0.55 | EPHB4 (0.45) | BACE1CTSDCYP11B2BACE2 | |
| SCHEMBL4023174 | 0.55 | FEN1 (0.51) | CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |