Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846105 | 0.94 | MAPK14 (0.49) | DHPSMAPK14DYRK1ACYP11B2ALDH1A1 | |
| SCHEMBL6847772 | 0.93 | DYRK1A (0.47) | DHPSMAPK14DYRK1ACYP11B2TNF | |
| SCHEMBL6663847 | 0.85 | MAPK14 (0.43) | DHPSMAPK14CYP11B2ALDH1A1CYP11B1 | |
| SCHEMBL7021321 | 0.85 | MAPT (0.44) | DHPSMAPK14DYRK1ACYP11B2CYP11B1 | |
| SCHEMBL7962053 | 0.85 | HTR6 (0.51) | MAPK14DYRK1ATNFL3MBTL1HTR6 | |
| SCHEMBL6845658 | 0.82 | VHL (0.47) | DHPSMAPK14CYP11B2CYP11B1MAPT | |
| SCHEMBL6844276 | 0.81 | CDC7 (0.44) | DHPSMAPK14CYP11B2ALDH1A1CYP11B1 | |
| SCHEMBL6846190 | 0.81 | DHPS (0.44) | DHPSMAPK14CYP11B2ALDH1A1CYP11B1 | |
| SCHEMBL6840695 | 0.81 | NPY5R (0.44) | DYRK1AKCNA5KCNH2 | |
| SCHEMBL6657827 | 0.81 | CYP17A1 (0.41) | MAPK14DYRK1ACYP11B2HTR6CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | BAYER PHARMACEUTICALS CORPORATION | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236110-A1 | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors | CYP17A1, IDO1, CYP21A2 | DHPS 81/4885MAPK14 3209/4885DYRK1A 1128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.