Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 0.89 |
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.89 |
| ▸ | USP2 | O75604 | 3/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.89 |
| ▸ | GAA | P10253 | 1/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.81 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tenoxicam SCHEMBL25343 | 0.94 | PTGS1 (1.00) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Tenoxicam SCHEMBL19307296 | 0.93 | PTGS1 (0.98) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL1444687 | 0.92 | ABCB11 (0.79) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL9114300 | 0.92 | PTGS1 (0.74) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Meloxicam SCHEMBL5273441 | 0.91 | PTGS1 (0.75) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL2680486 | 0.90 | PTGS1 (1.00) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL29352427 | 0.90 | PTGS1 (1.00) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL13462 | 0.90 | PTGS1 (1.00) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL15741898 | 0.90 | PTGS1 (1.00) | PTGS1KDM4EUSP2CYP2C9GAA | |
| Piroxicam SCHEMBL28536166 | 0.90 | PTGS1 (1.00) | PTGS1KDM4EUSP2CYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040258740-A1 | Transdermal delivery composition | NENE LABS | 2004-12-23 | — | — | US | claimed |
| EP-3752623-A1 | COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DELIVERY | Flagship Pioneering Innovations V, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019161281-A1 | COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DELIVERY | FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) | 2019-08-22 | — | — | WO | disclosed |
| US-20040258740-A1 | Transdermal delivery composition | NENE LABS | 2004-12-23 | — | — | US | disclosed |
| EP-1139773-A4 | CONTROLLING RELEASE OF ACTIVE AGENTS FROM A CHEWING GUM COATING | WRIGLEY W M JUN CO (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1139773-A1 | CONTROLLING RELEASE OF ACTIVE AGENTS FROM A CHEWING GUM COATING | WM. WRIGLEY JR. COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035295-A1 | CONTROLLING RELEASE OF ACTIVE AGENTS FROM A CHEWING GUM COATING | WM. WRIGLEY JR. COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |