Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meloxicam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.73 |
| ▸ | USP2 | O75604 | 3/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.73 |
| ▸ | EDNRA | P25101 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.67 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroxicam SCHEMBL2722775 | 0.93 | PTGS1 (0.85) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Piroxicam SCHEMBL6846290 | 0.91 | PTGS1 (0.89) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Lornoxicam SCHEMBL1412269 | 0.88 | ABCB11 (0.75) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Meloxicam SCHEMBL23589638 | 0.85 | PTGS1 (1.00) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Tenoxicam SCHEMBL25343 | 0.85 | PTGS1 (1.00) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Meloxicam SCHEMBL3752395 | 0.85 | PTGS1 (1.00) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Meloxicam SCHEMBL3576 | 0.85 | PTGS1 (1.00) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Piroxicam SCHEMBL9114300 | 0.85 | PTGS1 (0.74) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Piroxicam SCHEMBL1444687 | 0.85 | ABCB11 (0.79) | PTGS1PTGS2KDM4ECYP2C9USP2 | |
| Meloxicam SCHEMBL332632 | 0.84 | PTGS1 (0.98) | PTGS1PTGS2KDM4ECYP2C9USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11185590-B2 | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2021-11-30 | — | — | US | claimed |
| US-10071162-B2 | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2018-09-11 | — | — | US | claimed |
| US-20070202208-A1 | Anti-Inflammatory Pharmaceutical Compositions For Reducing Inflammation And The Treatment Or Prevention Of Gastric Toxicity | META PROTEOMICS, LLC | 2007-08-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070202208-A1 | Anti-Inflammatory Pharmaceutical Compositions For Reducing Inflammation And The Treatment Or Prevention Of Gastric Toxicity | VIP, ALPI, HPGDS | PTGS2 41/4885PTGS1 12/4885KDM4E 4629/4885 |
| US-11185590-B2 | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition | SI, PIM1, PIM3 | PTGS2 4664/4885PTGS1 4442/4885KDM4E 1216/4885 |
| US-10071162-B2 | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition | PIM1, PPARD, KCNN1 | PTGS2 4607/4885PTGS1 4253/4885KDM4E 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.