SCHEMBL6846291

SCHEMBL6846291

CNC(=O)[C@H](Cc1ccccc1)NC

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 12/20 0.58
FCER2 P06734 2/20 0.58
MMP2 P08253 14/20 0.55
MMP3 P08254 8/20 0.55
MMP9 P14780 4/20 0.53
MMP8 P22894 4/20 0.53
MMP7 P09237 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4428861 1.00 MMP1 (0.58) MMP1FCER2MMP2MMP3MMP9
SCHEMBL4428864 1.00 MMP1 (0.58) MMP1FCER2MMP2MMP3MMP9
SCHEMBL19361059 0.93 MMP1 (0.64) MMP1FCER2MMP2MMP3MMP9
SCHEMBL22962378 0.93 MMP1 (0.64) MMP1FCER2MMP2MMP3MMP9
SCHEMBL7439018 0.89 MMP1 (0.58) MMP1FCER2MMP2MMP3MMP9
SCHEMBL7439020 0.89 MMP1 (0.58) MMP1FCER2MMP2MMP3MMP9
SCHEMBL16254380 0.88 CYP2D6 (0.54) MMP1FCER2MMP2MMP3
SCHEMBL21988101 0.86 MMP1 (0.63) MMP1FCER2MMP2MMP3MMP9
SCHEMBL7762294 0.86 MMP1 (0.56) MMP1FCER2MMP2MMP3MMP9
SCHEMBL7762297 0.86 MMP1 (0.56) MMP1FCER2MMP2MMP3MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111479819-B Method for preparing peptide and method for treating alkali 中外制药株式会社 2024-06-14 CN disclosed
US-11492369-B2 Method for producing peptide, and method for processing bases CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-11-08 US disclosed
WO-2021159021-A1 LIPID PRODRUGS OF NEUROSTEROIDS PURETECH LYT, INC. (US) 2021-08-12 WO disclosed
US-20210061860-A1 PEPTIDE-COMPOUND CYCLIZATION METHOD CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-03-04 US disclosed
US-9409952-B2 Peptide-compound cyclization method CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-08-09 US disclosed
WO-2010022249-A2 MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA ENSEMBLE DISCOVERY CORPORATION (US) 2010-02-25 WO disclosed
US-20040176393-A1 Statin-MMP inhibitor combinations NEWTON ROGER SCHOFIELD (US) 2004-09-09 US disclosed
EP-1063991-A1 STATIN-MATRIX METALLOPROTEINASE INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY LLC (US) 2001-01-03 EP disclosed
EP-1047450-A1 ACE INHIBITOR-MMP INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 2000-11-02 EP disclosed
EP-0946166-A1 USE OF MATRIX METALLOPROTEINASE INHIBITORS FOR TREATING NEUROLOGICAL DISORDERS AND PROMOTING WOUND HEALING WARNER-LAMBERT COMPANY (US) 1999-10-06 EP disclosed
WO-1999047138-A1 STATIN-MATRIX METALLOPROTEINASE INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 1999-09-23 WO disclosed
WO-1999032150-A1 ACE INHIBITOR-MMP INHIBITOR COMBINATIONS WARNER-LAMBERT COMPANY (US) 1999-07-01 WO disclosed
WO-1998026773-A1 USE OF MATRIX METALLOPROTEINASE INHIBITORS FOR TREATING NEUROLOGICAL DISORDERS AND PROMOTING WOUND HEALING WARNER-LAMBERT COMPANY (US) 1998-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040176393-A1 Statin-MMP inhibitor combinations MMP9, TIMP3, MMP3 MMP1 20/4885FCER2 4226/4885MMP2 19/4885
US-20210061860-A1 PEPTIDE-COMPOUND CYCLIZATION METHOD VIP, NGLY1, GLP1R MMP1 2702/4885FCER2 4449/4885MMP2 1620/4885
US-11492369-B2 Method for producing peptide, and method for processing bases VIP, NPPA, PTMS MMP1 3040/4885FCER2 4689/4885MMP2 2019/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.