Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795502 | 0.94 | KIF11 (0.44) | KIF11MAPK14BACE1ALDH1A1TSHR | |
| SCHEMBL8529939 | 0.86 | GSTP1 (0.47) | ALDH1A1TSHRMEN1KMT2ALTA4H | |
| SCHEMBL6821467 | 0.86 | SLC6A4 (0.41) | KIF11SCN9ALTA4H | |
| SCHEMBL7703136 | 0.84 | LTA4H (0.46) | ALDH1A1TSHRMEN1KMT2ALTA4H | |
| SCHEMBL16719650 | 0.80 | NOTUM (0.39) | MAPK14TSHRLTA4H | |
| SCHEMBL8315326 | 0.78 | MAOB (0.44) | ALDH1A1TSHRMEN1KMT2ALTA4H | |
| SCHEMBL10965408 | 0.78 | GSTP1 (0.37) | ALDH1A1TSHRMEN1KMT2ALTA4H | |
| SCHEMBL8531326 | 0.77 | LTA4H (0.53) | ALDH1A1TSHRMEN1KMT2ALTA4H | |
| SCHEMBL16719443 | 0.76 | PGR (0.40) | BACE1TSHRMEN1KMT2ALTA4H | |
| SCHEMBL8078153 | 0.76 | KIF11 (0.43) | KIF11BACE1ALDH1A1TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774125-B2 | TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. | 2004-08-10 | — | — | US | claimed |