Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849158 | 0.89 | LTA4H (0.53) | LTA4HNPC1RAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL9114061 | 0.84 | CYP2C19 (0.67) | SMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL3718057 | 0.82 | LTA4H (0.61) | LTA4HNPC1RAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL1069341 | 0.81 | LTA4H (0.53) | LTA4HNPC1RAB9ASMN1; SMN2ALOX5 | |
| SCHEMBL10410136 | 0.80 | LTA4H (0.52) | LTA4HNPC1RAB9ASMN1; SMN2ALOX5 | |
| SCHEMBL14021656 | 0.80 | ESR1 (0.72) | LTA4HNPC1RAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL8880882 | 0.80 | ALOX5 (0.62) | FFAR1ALOX5 | |
| SCHEMBL31579489 | 0.80 | LTA4H (0.60) | LTA4HNPC1RAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL5070331 | 0.79 | CYP3A4 (0.50) | RAB9AALDH1A1CYP2C19 | |
| SCHEMBL6509628 | 0.79 | LTA4H (0.51) | LTA4HNPC1RAB9ASMN1; SMN2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770763-B2 | CONTACTING PYRROLIDINONE-N-ACETIC ACID DERIVATIVE WITH BASE IN APROTIC SOLVENT; AMINATION WITH ELECTROPHILIC NITROGEN COMPOUND; REDUCTION, HYDROLYSIS; TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AND METALLOPROTEINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-03 | — | — | US | disclosed |
| US-20030236401-A1 | Asymmetric synthesis of amino-pyrrolidinones | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-25 | — | — | US | disclosed |
| WO-2003104220-A1 | ASYMETRIC SYNTHESIS OF AMINO-PYRROLIDINONES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236401-A1 | Asymmetric synthesis of amino-pyrrolidinones | ADAM17, EPRS1, ADAM8 | LTA4H 3916/4885NPC1 2276/4885RAB9A 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.