Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851115 | 0.88 | TPMT (0.52) | ALDH1A1HPGDHSD17B10BCL2L1DHODH | |
| SCHEMBL6851219 | 0.88 | PTGER1 (0.56) | ALDH1A1HPGDHSD17B10BCL2L1DHODH | |
| SCHEMBL28409527 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HPGDHSD17B10BCL2L1DHODH | |
| SCHEMBL28409543 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HPGDHSD17B10BCL2L1DHODH | |
| SCHEMBL29908924 | 0.87 | DHODH (0.57) | DHODHTSHRTTRPOLBKMT2A | |
| SCHEMBL29908910 | 0.85 | DHODH (0.55) | DHODHTSHRTTRPOLBKMT2A | |
| SCHEMBL442496 | 0.85 | KMO (0.63) | ALDH1A1HPGDHSD17B10BCL2L1KMO | |
| SCHEMBL9609308 | 0.84 | TSHR (0.57) | ALDH1A1HPGDHSD17B10BCL2L1DHODH | |
| Hydrochloric Acid SCHEMBL27574419 | 0.83 | KMO (0.61) | ALDH1A1HPGDHSD17B10BCL2L1KMO | |
| 2-Phenylphenol SCHEMBL9013767 | 0.82 | ALDH1A1 (0.71) | ALDH1A1HPGDHSD17B10BCL2L1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |