2-Pyrrolidone

2-Pyrrolidone

SCHEMBL6849688

NC(N)=O.O=C1CCCN1

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 2/20 0.75
CRBN Q96SW2 4/20 0.64
FKBP5 Q13451 1/20 0.64
KDM4E B2RXH2 3/20 0.44
GAA P10253 1/20 0.44
POLB P06746 1/20 0.44
NNMT P40261 1/20 0.37
KMT2A Q03164 1/20 0.36
MAPT P10636 2/20 0.32
HSP90AA1 P07900 1/20 0.31
MAPK8 P45983 1/20 0.31
CSNK1A1 P48729 1/20 0.31
LIMK1 P53667 1/20 0.31
MAP2K1 Q02750 1/20 0.31
PRKAA1 Q13131 1/20 0.31
DYRK1A Q13627 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
DYRK1B Q9Y463 1/20 0.31
LMNA P02545 2/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Pyrrolidone SCHEMBL28310048 0.95 OR51E2 (0.68) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL4666153 0.93 OR51E2 (0.71) OR51E2CRBNFKBP5KDM4EGAA
Caprolactam SCHEMBL13571212 0.91 CRBN (0.73) OR51E2CRBNFKBP5KDM4EGAA
Caprolactam SCHEMBL8561273 0.91 CRBN (0.73) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL3729403 0.91 OR51E2 (0.68) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL14977810 0.87 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL6929736 0.87 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL353224 0.87 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL14977562 0.87 OR51E2 (0.79) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL4655461 0.87 OR51E2 (0.88) OR51E2CRBNFKBP5KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0830421-A1 MODIFIED AMINO CROSSLINKING AGENTS CYTEC TECHNOLOGY CORP. (US) 1998-03-25 EP claimed
US-5665852-A USEFUL IN POWDER COATING COMPOSITIONS CYTEC TECHNOLOGY CORP. (US) 1997-09-09 US claimed
WO-1996040825-A1 MODIFIED AMINO CROSSLINKING AGENTS CYTEC TECHNOLOGY CORP. (US) 1996-12-19 WO claimed
CN-104749908-B Electrophotographic photosensitive element, its production method, handle box and electronic photographing device 佳能株式会社 2019-05-03 CN disclosed
CN-106920694-B Conductive material and capacitor 财团法人工业技术研究院 2019-04-05 CN disclosed
CN-108884051-A Dione compounds, pyrazole compound and the method for manufacturing pyrazole compound that halogen replaces 索尔维公司 2018-11-23 CN disclosed
CN-104177951-B Anti-dazzle coating composition and its preparation and use 北京化工大学 2018-07-10 CN disclosed
CN-104321327-B Double (thiadiazoles) derivant of benzo and the organic electronic device containing it 宇部兴产株式会社 2017-03-01 CN disclosed
CN-102869629-B Anti-glare surface treatment method and article thereof 康宁股份有限公司 2017-03-01 CN disclosed
CN-105934448-A (meth)acrylate compound, (meth)acrylic copolymer and photosensitive resin composition containing same 三菱瓦斯化学株式会社 2016-09-07 CN disclosed
CN-101855302-B Self-dispersed pigments and methods for making and using the same SENSIENT COLORS INC. (US) 2014-10-01 CN disclosed
WO-1996040825-A1 MODIFIED AMINO CROSSLINKING AGENTS CYTEC TECHNOLOGY CORP. (US) 1996-12-19 WO disclosed
EP-0691953-A1 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS G.D. SEARLE & CO. (US) 1996-01-17 EP disclosed
EP-0561941-B1 N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS SEARLE & CO (US) 1995-01-04 EP disclosed
WO-1994022820-A1 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS G.D. SEARLE & CO. (US) 1994-10-13 WO disclosed
US-5314886-A N-substituted lactams useful as cholecystokinin antagonists G. D. SEARLE & CO. (US) 1994-05-24 US disclosed
EP-0561941-A1 N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS. SEARLE & CO (US) 1993-09-29 EP disclosed
US-5202344-A Disorders of the gastrointestinal, central nervous system and appetite regulatory systems G. D. SEARLE & CO. (US) 1993-04-13 US disclosed
WO-1992010476-A1 N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS G.D. SEARLE & CO. (US) 1992-06-25 WO disclosed
US-4317673-A MIXTURE OF /-TRIFLUOROPHENYL; 3-CHLORO, 4-CHLOROMETHYL-2-PYRROLIDONE AND AN N-P-CHLOROPHENOXYPHENYL-N*,N*-DIALKYL UREA STAUFFER CHEMICAL COMPANY (US) 1982-03-02 US disclosed