Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6846809 | 0.99 | CRHBP (0.33) | CRHBPCRHR2PTGS1PTGS2 | |
| SCHEMBL5664567 | 0.78 | POLB (0.32) | CRHBPCRHR2PTGS1PTGS2 | |
| SCHEMBL4462509 | 0.74 | — | — | |
| SCHEMBL27850665 | 0.69 | THRB (0.34) | TDP1 | |
| SCHEMBL6576092 | 0.69 | CRHBP (0.32) | CRHBPCRHR2ALDH1A1TDP1 | |
| SCHEMBL8032075 | 0.64 | — | — | |
| SCHEMBL27638427 | 0.64 | ALDH1A1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL27605635 | 0.63 | — | — | |
| SCHEMBL8779775 | 0.62 | — | — | |
| SCHEMBL6851292 | 0.62 | GRM2 (0.33) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |