Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27819858 | 0.80 | NPC1 (0.42) | LMNAGAAKMT2A | |
| SCHEMBL11540720 | 0.73 | CCNE2 (0.48) | LMNAHDAC1ACSS2KMT2A | |
| SCHEMBL11544477 | 0.69 | TP53 (0.41) | GAAKMT2A | |
| SCHEMBL27819859 | 0.68 | ATM (0.33) | HDAC1 | |
| SCHEMBL11542530 | 0.68 | ACSS2 (0.37) | LMNAACSS2KMT2A | |
| SCHEMBL1127860 | 0.67 | — | — | |
| SCHEMBL27798699 | 0.66 | NPC1 (0.41) | KMT2A | |
| SCHEMBL22118870 | 0.66 | DAGLA (0.40) | TSHR | |
| SCHEMBL25144893 | 0.65 | FPR3 (0.34) | — | |
| SCHEMBL4034904 | 0.64 | DRD2 (0.54) | LMNAHDAC1GAATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467976-A1 | N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES | AstraZeneca AB (SE) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059893-A1 | N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2003-07-24 | — | — | WO | disclosed |