Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.32 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.32 |
| ▸ | CPT2 known ✓ | P23786 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 5/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4917599 | 0.97 | BBOX1 (0.58) | BBOX1CA1CA9SLC22A16MEN1 | |
| Fumaric Acid SCHEMBL4917936 | 0.97 | BBOX1 (0.58) | BBOX1CA1CA9SLC22A16MEN1 | |
| Fumaric Acid SCHEMBL4951502 | 0.97 | BBOX1 (0.58) | BBOX1CA1CA9SLC22A16MEN1 | |
| Fumaric Acid SCHEMBL4926059 | 0.88 | BBOX1 (0.50) | BBOX1CA1CA9TSHR | |
| Fumaric Acid SCHEMBL4953256 | 0.88 | BBOX1 (0.50) | BBOX1CA1CA9TSHR | |
| Fumaric Acid SCHEMBL4926168 | 0.88 | BBOX1 (0.50) | BBOX1CA1CA9TSHR | |
| Fumaric Acid SCHEMBL2457500 | 0.87 | BBOX1 (0.48) | BBOX1CA1CA9FFAR3HDAC3 | |
| Fumaric Acid SCHEMBL4953861 | 0.84 | BBOX1 (0.50) | BBOX1CA1CA9SLC22A16FFAR3 | |
| Tetrylammonium SCHEMBL3864261 | 0.84 | BBOX1 (0.44) | BBOX1CA1CA9FFAR3HDAC3 | |
| Tetrylammonium SCHEMBL11155692 | 0.84 | BBOX1 (0.44) | BBOX1CA1CA9FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708452-B1 | Ion-conductive polymer electrolyte, method for producing the electrolyte and capacitors using the electrolyte | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6043975-A | ELECTROLYTE IS COPOLYMER OF A HYDROXYALKYL (METH) ACRYLATE OR VINYLIDENE CARBONATE AND AMMONIUM CARBOXYLATE SUCH AS TRIETHYLMETHYLAMMONIUM HYDROGEN MALEATE (MAH3E1M), IN WHICH IONS DISSOCIATED FROM MAH3E1M SERVE AS THE CONDUCTIVE SPECIES | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0684619-B1 | Ion-conductive polymer electrolyte and electrolytic capacitor using the same | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2000-03-08 | — | — | EP | disclosed |
| US-5900182-A | SOLID ELECTROLYTE CONTAINING COPOLYMERS OF HYDROXYALKYL ACRYLATES AND QUATERNARY AMMONIUM OR MORPHOLINIUM CARBOXYLATES OR DICARBOXYLATES, STORAGE STABILITY, HEAT RESISTANCE, HIGH CONDUCTIVITY | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1999-05-04 | — | — | US | disclosed |
| EP-0708452-A1 | Ion-conductive polymer electrolyte, method for producing the electrolyte and capacitors using the electrolyte | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1996-04-24 | — | — | EP | disclosed |