Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aliskiren. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN known ✓ | P00797 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aliskiren SCHEMBL3476540 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL3397036 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL2478013 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL29521564 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL455490 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL3476535 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL3476537 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL13320734 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL13351616 | 1.00 | REN (1.00) | REN | |
| Aliskiren SCHEMBL7965529 | 1.00 | REN (1.00) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220663-A1 | SOLID FORMS OF ALISKIREN HEMIFUMARATE AND PROCESSES FOR PREPARATION THEREOF | TEVA PHARMACEUTICALS USA, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| US-8148576-B2 | Solid state forms of aliskiren compounds | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-04-03 | — | — | US | disclosed |
| US-8148576-B2 | Solid state forms of aliskiren compounds | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-04-03 | — | — | US | disclosed |
| US-20120029083-A1 | POLYMORPHIC FORMS OF ALISKIREN HEMIFUMARATE AND PROCESS FOR PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES, LTD. | 2012-02-02 | — | — | US | disclosed |
| WO-2011028919-A2 | SOLID FORMS OF ALISKIREN HEMIFUMARATE AND PROCESSES FOR PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2011-03-10 | — | — | WO | disclosed |
| US-20100197793-A1 | SOLID STATE FORMS OF ALISKIREN COMPOUNDS | TEVA PHARMACEUTICALS USA, INC. | 2010-08-05 | — | — | US | disclosed |
| US-20100197793-A1 | SOLID STATE FORMS OF ALISKIREN COMPOUNDS | TEVA PHARMACEUTICALS USA, INC. | 2010-08-05 | — | — | US | disclosed |
| US-20100029774-A1 | ALISKIREN MONOFUMARATE AND PROCESSES FOR PREPARATION THEREOF | TEVA PHARMACEUTICALS USA, INC. | 2010-02-04 | — | — | US | disclosed |
| WO-2009143423-A1 | ALISKIREN MONOFUMARATE AND PROCESSES FOR PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009064479-A1 | POLYMORPHIC FORMS OF ALISKIREN HEMIFUMARATE AND PROCESS FOR PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029774-A1 | ALISKIREN MONOFUMARATE AND PROCESSES FOR PREPARATION THEREOF | FGFR1, REN, FH | REN 2/4885 |
| US-20120220663-A1 | SOLID FORMS OF ALISKIREN HEMIFUMARATE AND PROCESSES FOR PREPARATION THEREOF | FGFR1, CYP4F11, REN | REN 3/4885 |
| US-20120029083-A1 | POLYMORPHIC FORMS OF ALISKIREN HEMIFUMARATE AND PROCESS FOR PREPARATION THEREOF | FGFR1, HK1, KHK | REN 98/4885 |
| US-20100197793-A1 | SOLID STATE FORMS OF ALISKIREN COMPOUNDS | REN, AGTR1, AGTR2 | REN 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.