Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 6/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852831 | 0.84 | KEAP1 (0.36) | KEAP1NFE2L2ARMRGPRX4PPARA | |
| SCHEMBL29800201 | 0.79 | MAPK1 (0.36) | KEAP1NFE2L2 | |
| SCHEMBL6852995 | 0.71 | KEAP1 (0.47) | KEAP1NFE2L2ARMCL1RORC | |
| SCHEMBL3157117 | 0.70 | PDE10A (0.32) | — | |
| SCHEMBL31041199 | 0.70 | PDE10A (0.32) | — | |
| SCHEMBL6849586 | 0.70 | OPRK1 (0.42) | KEAP1NFE2L2ARMRGPRX4PPARA | |
| SCHEMBL6856861 | 0.70 | THRB (0.51) | KEAP1NFE2L2PPARA | |
| SCHEMBL7089153 | 0.69 | KEAP1 (0.46) | KEAP1NFE2L2ARHTR2AHTR2C | |
| SCHEMBL23824146 | 0.69 | FFAR4 (0.48) | MRGPRX4 | |
| SCHEMBL6855496 | 0.68 | CTRC (0.43) | KEAP1NFE2L2MRGPRX4PPARAADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777442-B2 | Diphenyl derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-17 | — | — | US | disclosed |
| EP-1370523-A1 | DIPHENYL DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-20030105078-A1 | Diphenyl derivatives | BAYER AKTIENGESSELLSCHAFT (DE) | 2003-06-05 | — | — | US | disclosed |
| WO-2002072539-A1 | DIPHENYL DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105078-A1 | Diphenyl derivatives | DPP4, DPP3, DPM1 | KEAP1 1863/4885NFE2L2 78/4885AR 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.