Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383954 | 0.72 | USP2 (0.43) | POLBESR1HCAR2ALDH1A1HTT | |
| SCHEMBL31389644 | 0.66 | POLB (0.37) | POLBESR1HCAR2PLATALDH1A1 | |
| SCHEMBL25433166 | 0.61 | GRM5 (0.42) | POLBESR1HCAR2ALDH1A1 | |
| SCHEMBL25433533 | 0.61 | GRM5 (0.42) | POLBESR1HCAR2ALDH1A1 | |
| SCHEMBL2152111 | 0.59 | HCAR2 (0.41) | POLBHCAR2HCAR3DAOALDH1A1 | |
| SCHEMBL31389630 | 0.58 | RIPK1 (0.39) | POLBESR1HCAR2PLATDAO | |
| SCHEMBL3310783 | 0.58 | HDAC6 (0.41) | POLBALDH1A1APOBEC3AAPOBEC3G | |
| SCHEMBL23000276 | 0.58 | POLB (0.33) | POLBHCAR2DAOALDH1A1APOBEC3A | |
| SCHEMBL12282789 | 0.58 | PDCD1 (0.43) | POLBHCAR2PLATAPOBEC3AAPOBEC3G | |
| SCHEMBL1815818 | 0.58 | KMO (0.42) | POLBALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831074-B2 | Inhibitors of cyclic guanosine 3',5'-monophosphate phosphodiesterases (cGMP PDES); for use in therapy of sexual disorders | PFIZER INC | 2004-12-14 | — | — | US | disclosed |