Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.39 |
| ▸ | GSK3A | P49840 | 10/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6860968 | 0.81 | GSK3A (0.44) | GSK3BGSK3ADUSP3PIK3CGMAPT | |
| SCHEMBL1116221 | 0.78 | HTR2A (0.41) | GSK3BGSK3ADUSP3PIK3CGFAAH | |
| SCHEMBL1116224 | 0.78 | HTR2A (0.41) | GSK3BGSK3ADUSP3PIK3CGFAAH | |
| SCHEMBL1116268 | 0.77 | ALDH1A1 (0.43) | PIK3CGFAAHCES1MAPTLMNA | |
| SCHEMBL6859360 | 0.71 | GSK3A (0.43) | GSK3BGSK3ADUSP3PIK3CGMAPT | |
| SCHEMBL6858664 | 0.63 | GSK3A (0.74) | GSK3BGSK3ADUSP3MAPTRECQL | |
| SCHEMBL30961329 | 0.62 | FAAH (0.46) | PIK3CGFAAHCES1QPCTQPCTL | |
| SCHEMBL6858605 | 0.62 | PLAU (0.36) | FAAHCES1QPCTQPCTL | |
| SCHEMBL16734472 | 0.60 | PIM1 (0.44) | GSK3BPIK3CGMAPTLMNAMEN1 | |
| SCHEMBL29225233 | 0.60 | FAAH (0.45) | FAAHCES1MAPTLMNAQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |