Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.72 |
| ▸ | CTSB | P07858 | 2/20 | 0.72 |
| ▸ | CTSK | P43235 | 2/20 | 0.72 |
| ▸ | BCHE | P06276 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858391 | 0.84 | CTSK (1.00) | CTSLCTSBCTSKALDH1A1CTSS | |
| SCHEMBL23052424 | 0.80 | NPY5R (0.69) | BCHEMAOBNPY5RHDAC3HDAC4 | |
| SCHEMBL6858424 | 0.80 | CTSL (0.65) | CTSLCTSBCTSKBCHELMNA | |
| SCHEMBL4393015 | 0.75 | NPY5R (0.70) | BCHEMAOBNPY5RHDAC3HDAC4 | |
| SCHEMBL932265 | 0.75 | NPY5R (0.66) | BCHEMAOBNPY5RHDAC3HDAC4 | |
| SCHEMBL13768018 | 0.75 | NPY5R (0.73) | BCHEMAOBNPY5RHDAC3HDAC4 | |
| SCHEMBL4393007 | 0.75 | NPY5R (0.70) | BCHEMAOBNPY5RHDAC3HDAC4 | |
| SCHEMBL6856492 | 0.74 | CTSK (1.00) | CTSLCTSBCTSKALDH1A1CTSS | |
| SCHEMBL13644753 | 0.74 | USP30 (0.73) | CTSLCTSBCTSKALDH1A1CTSS | |
| SCHEMBL7995936 | 0.74 | USP30 (0.73) | CTSLCTSBCTSKALDH1A1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6835727-B2 | Bone disorders; osteoporosis; rheumatic diseases | MERCK FROSST CANADA & CO. (CA) | 2004-12-28 | — | — | US | claimed |
| US-20030229226-A1 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA LTD. (CA) | 2003-12-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229226-A1 | Cathepsin cysteine protease inhibitors | CTSK, CTSZ, CTSE | CTSL 10/4885CTSB 5/4885CTSK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.