SCHEMBL686258

SCHEMBL686258

O=C(N/N=C/c1cc(C(F)(F)F)ccc1O)c1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.73
KDM4E B2RXH2 3/20 0.73
KMT2A Q03164 3/20 0.73
HTT P42858 3/20 0.73
PTBP1 P26599 2/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
POLB P06746 1/20 0.73
TDP1 Q9NUW8 1/20 0.73
PHGDH O43175 1/20 0.64
MAPT P10636 4/20 0.58
MEN1 O00255 2/20 0.58
HSP90AA1 P07900 1/20 0.58
GAA P10253 1/20 0.58
HPGD P15428 1/20 0.58
ALOX12 P18054 1/20 0.58
ALOX5 P09917 1/20 0.58
PTGS2 P35354 1/20 0.58
NPC1 O15118 2/20 0.56
RAB9A P51151 2/20 0.56
PKM P14618 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685583 0.90 KMT2A (0.73) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL686241 0.90 PHGDH (0.67) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL685734 0.89 KMT2A (0.69) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL20587748 0.88 KMT2A (0.68) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL22179548 0.88 KMT2A (0.68) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL686260 0.88 KDM4E (0.68) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL20587749 0.88 KMT2A (0.68) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL686554 0.88 KDM1A (0.69) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL686354 0.87 KDM1A (0.69) LMNAKDM4EKMT2AHTTPTBP1
SCHEMBL686455 0.87 KMT2A (0.70) LMNAKDM4EKMT2AHTTPTBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-06-14 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 LMNA 4808/4885KDM4E 1473/4885KMT2A 1362/4885
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 LMNA 4567/4885KDM4E 1286/4885KMT2A 1224/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS LMNA 4736/4885KDM4E 4139/4885KMT2A 2866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.