Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6871379 | 0.88 | ADORA2A (0.59) | ADORA2AALDH1A1HSD17B10F12KDM4E | |
| SCHEMBL6863389 | 0.86 | NPC1 (0.47) | ADORA2APOLBMEN1KMT2AHPGD | |
| SCHEMBL6869915 | 0.83 | ADORA2A (0.57) | ADORA2AALDH1A1HSD17B10F12KDM4E | |
| SCHEMBL6870369 | 0.81 | ADORA2A (0.61) | ADORA2AF12F2 | |
| SCHEMBL6870136 | 0.81 | ADORA2A (0.61) | ADORA2AF12F2 | |
| SCHEMBL6870495 | 0.81 | POLB (0.42) | ADORA2APOLBALDH1A1MEN1KMT2A | |
| SCHEMBL6863310 | 0.81 | ADORA2A (0.64) | ADORA2AALDH1A1HPGDHSD17B10F12 | |
| SCHEMBL6868478 | 0.80 | ADORA2A (0.64) | ADORA2AALDH1A1HPGDHSD17B10F12 | |
| SCHEMBL6869714 | 0.80 | ADORA2A (0.43) | ADORA2APOLBALDH1A1MEN1KMT2A | |
| SCHEMBL6871898 | 0.79 | ADORA2A (0.62) | ADORA2AMEN1KMT2AF12F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |