Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870707 | 0.89 | KMT2A (0.43) | ADORA2AALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL6863739 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL6869746 | 0.87 | PLAU (0.43) | ADORA2AALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6870631 | 0.86 | LMNA (0.48) | ADORA2AADORA1TP53ALDH1A1KMT2A | |
| SCHEMBL6872215 | 0.85 | EGLN2 (0.42) | SMN1; SMN2ADORA2AADORA1ALDH1A1KMT2A | |
| SCHEMBL6872375 | 0.84 | ADORA2A (0.60) | SMN1; SMN2ADORA2AADORA1TP53KMT2A | |
| SCHEMBL6870664 | 0.82 | TP53 (0.45) | SMN1; SMN2ADORA2AADORA1TP53ALDH1A1 | |
| SCHEMBL6868276 | 0.82 | TP53 (0.44) | SMN1; SMN2ADORA2AADORA1TP53ALDH1A1 | |
| SCHEMBL6871216 | 0.82 | ADORA2A (0.44) | SMN1; SMN2ADORA2AADORA1TP53ALDH1A1 | |
| SCHEMBL6870348 | 0.81 | ADORA2A (0.56) | SMN1; SMN2ADORA2ATP53ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |