Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867448 | 0.89 | HTT (0.56) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL6863096 | 0.86 | SMN1; SMN2 (0.43) | LMNATP53CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6870707 | 0.86 | KMT2A (0.43) | LMNAMAPTKMT2AADORA2AALDH1A1 | |
| SCHEMBL6869746 | 0.84 | PLAU (0.43) | LMNACYP1A2CYP3A4CYP2C19MAPT | |
| SCHEMBL6869675 | 0.84 | ALDH1A1 (0.54) | LMNATP53CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6873996 | 0.82 | ADORA2A (0.55) | LMNATP53MAPTHTTADORA2A | |
| SCHEMBL7114944 | 0.82 | ADORA2A (0.54) | LMNATP53CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6863761 | 0.82 | HPGD (0.46) | LMNATP53CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6871380 | 0.82 | MAPT (0.46) | LMNATP53MAPTHTTADORA2A | |
| SCHEMBL6872062 | 0.81 | TP53 (0.47) | LMNATP53CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |