Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 13/20 | 0.62 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | PAK3 | O75914 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863997 | 0.86 | EPHX2 (0.47) | EPHX2CXCR3CYP2D6 | |
| SCHEMBL6863510 | 0.86 | EPHX2 (0.45) | EPHX2CXCR3 | |
| SCHEMBL12014318 | 0.85 | CXCR3 (0.62) | EPHX2CXCR3CYP2D6PAK3PAK1 | |
| SCHEMBL6862576 | 0.84 | EPHX2 (0.44) | EPHX2CXCR3 | |
| SCHEMBL12014289 | 0.82 | MGLL (0.46) | EPHX2CXCR3 | |
| SCHEMBL12005298 | 0.81 | S1PR2 (0.44) | EPHX2 | |
| SCHEMBL12015274 | 0.80 | LMNA (0.40) | EPHX2CYP2D6 | |
| SCHEMBL20041091 | 0.79 | EPHX2 (0.80) | EPHX2CXCR3 | |
| SCHEMBL17130479 | 0.77 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL23736048 | 0.76 | EPHX2 (0.75) | EPHX2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
| WO-2011032291-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD . (CA) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | CACNA1G, CACNA1I, CACNA1H | EPHX2 3610/4885CXCR3 2678/4885CYP2D6 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.