Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857824 | 0.76 | PLA2G7 (0.60) | ALDH1A1PLA2G7SLC22A12MAPT | |
| SCHEMBL25374578 | 0.68 | ALDH1A1 (0.57) | ALDH1A1SLC22A12MAPTIMPDH2 | |
| SCHEMBL6863297 | 0.68 | GRM4 (0.43) | ALDH1A1PLA2G7SLC22A12ACLY | |
| SCHEMBL13848475 | 0.68 | NPY2R (0.47) | ALDH1A1MAPT | |
| SCHEMBL6863684 | 0.67 | ALDH1A1 (0.60) | ALDH1A1PLA2G7SLC22A12MAPTIMPDH2 | |
| SCHEMBL6865614 | 0.66 | ALDH1A1 (0.64) | ALDH1A1MAPT | |
| SCHEMBL5029109 | 0.66 | ALDH1A1 (0.63) | ALDH1A1IMPDH2AR | |
| SCHEMBL4256511 | 0.66 | LMNA (0.48) | ALDH1A1TP53 | |
| SCHEMBL9703034 | 0.65 | ALDH1A1 (0.47) | ALDH1A1MAPT | |
| SCHEMBL5776454 | 0.65 | MEN1 (0.51) | ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |