Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875163 | 1.00 | EIF2AK2 (0.46) | EIF2AK2CYP1A2CYP2D6LMNAUSP2 | |
| SCHEMBL6457485 | 0.90 | EIF2AK2 (0.43) | EIF2AK2CYP1A2CYP2D6LMNAUSP2 | |
| SCHEMBL6462830 | 0.87 | ADRA2A (0.43) | LMNAKMT2AHTR1AHTR2AMTNR1A | |
| SCHEMBL6868965 | 0.87 | ADRA2A (0.43) | LMNAKMT2AHTR1AHTR2AMTNR1A | |
| SCHEMBL6875264 | 0.85 | LMNA (0.54) | LMNAALDH1A1KMT2AHTR1A | |
| SCHEMBL6878307 | 0.84 | TSHR (0.46) | EIF2AK2CYP1A2CYP2D6LMNAUSP2 | |
| SCHEMBL6878316 | 0.84 | TSHR (0.46) | EIF2AK2CYP1A2CYP2D6LMNAUSP2 | |
| SCHEMBL13797393 | 0.80 | MCHR1 (0.55) | CYP1A2CYP2D6LMNAUSP2CYP3A4 | |
| SCHEMBL6874191 | 0.79 | BCHE (0.44) | CYP1A2CYP2D6LMNAALDH1A1ALOX15 | |
| SCHEMBL6458578 | 0.79 | BCHE (0.44) | CYP1A2CYP2D6LMNAALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |