Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264174 | 0.79 | CA2 (0.52) | TDP1PPARALTA4HEPHX2 | |
| SCHEMBL306550 | 0.78 | LMNA (0.64) | MAOAMAOBLTA4HEPHX2 | |
| SCHEMBL23573012 | 0.78 | FFAR1 (0.61) | MAOAMAOBPPARGPPARALTA4H | |
| Hydrochloric Acid SCHEMBL3330629 | 0.78 | SIGMAR1 (0.51) | — | |
| SCHEMBL9145079 | 0.77 | TDP1 (0.46) | MAOBTDP1PPARA | |
| SCHEMBL3289628 | 0.77 | THRB (0.47) | PPARGPPARA | |
| SCHEMBL4715391 | 0.77 | TAAR1 (0.59) | MAOB | |
| SCHEMBL8885 | 0.77 | LTA4H (0.50) | MAOAMAOBTDP1LTA4H | |
| SCHEMBL55138 | 0.77 | MAOB (0.72) | MAOAMAOBTDP1FFAR1 | |
| SCHEMBL12506236 | 0.77 | MAOB (0.72) | MAOAMAOBTDP1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004578-B1 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | PFIZER PROD INC (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6114361-A | INHIBITORS OF MATRIX METALLOPROTEINASES AND REPROLYSIN; ADMINISTERING TO TREAT CONDITIONS WHICH CAN BE TREATED BY THE INHIBITION OF THESE ENZYMES | PFIZER INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-1004578-A2 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |