Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870625 | 0.90 | MAPK10 (0.45) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL6869924 | 0.90 | CHRM4 (0.47) | KDM4EDHFRADORA2AALDH1A1MEN1 | |
| SCHEMBL6863441 | 0.86 | HPGD (0.45) | KDM4EALDH1A1MEN1GAAKMT2A | |
| SCHEMBL6873737 | 0.85 | L3MBTL1 (0.43) | KDM4EADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL6867467 | 0.85 | KDM4E (0.46) | KDM4EADORA2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6871432 | 0.81 | ADORA2A (0.40) | ADORA2AADORA1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6867257 | 0.80 | ADORA2A (0.55) | ADORA3ADORA2AADORA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6867623 | 0.79 | F2 (0.43) | KDM4EADORA2AADORA1ALDH1A1GAA | |
| SCHEMBL6872077 | 0.78 | ADORA2A (0.42) | KDM4EDHFRADORA2AADORA1ALDH1A1 | |
| SCHEMBL6872431 | 0.78 | HDAC3 (0.40) | KDM4EADORA2ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |