Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866973 | 0.85 | BACE1 (0.48) | EGLN2KDM4EALDH1A1POLBMAPT | |
| SCHEMBL6870605 | 0.82 | ADORA2A (0.58) | ADORA2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL6869746 | 0.82 | PLAU (0.43) | ADORA2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL6867215 | 0.81 | PLAU (0.47) | MEN1POLBHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL6871283 | 0.80 | PTGER2 (0.44) | ADORA2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL6872215 | 0.80 | EGLN2 (0.42) | ADORA2AEGLN2KDM4EALDH1A1MAPT | |
| SCHEMBL6870649 | 0.80 | ADORA2A (0.61) | ADORA2ASMN1; SMN2 | |
| SCHEMBL6871806 | 0.80 | ADORA2A (0.42) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL6869803 | 0.80 | ADORA2A (0.41) | ADORA2AMEN1POLBKMT2AKDR | |
| SCHEMBL6863099 | 0.79 | ADORA2A (0.45) | ADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |