Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 7/20 | 0.49 |
| ▸ | MAOB | P27338 | 7/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29394922 | 1.00 | PIM1 (0.52) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL27676782 | 0.95 | PIM1 (0.49) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL31395242 | 0.88 | PIM1 (0.50) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL31556430 | 0.88 | SRC (0.45) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL24512554 | 0.88 | SRC (0.45) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL18002541 | 0.87 | PIM1 (0.46) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL5576877 | 0.85 | SRC (0.49) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL896842 | 0.84 | PIM1 (0.56) | PIM1PIM2SRCMAOAMAOB | |
| SCHEMBL18002211 | 0.83 | DRD1 (0.50) | PIM1PIM2CHRM2CHRM1CHRM3 | |
| SCHEMBL21287982 | 0.82 | PIM1 (0.50) | PIM1PIM2CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093410-A | Preparation method of beta-carboline compound | 南京工业大学 | 2022-09-23 | — | — | CN | claimed |
| CN-113929695-A | Sulfenimide psoralen derivatives, and preparation method and application thereof | 南开大学 | 2022-01-14 | — | — | CN | claimed |
| CN-110003200-A | P2X7 regulator | 詹森药业有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-105209464-B | P2X7 modulators | 詹森药业有限公司 | 2019-01-01 | — | — | CN | claimed |
| CN-108395396-A | A kind of preparation method of chirality vicinal amino alcohols intermediate and antagonist and the like | 复旦大学 | 2018-08-14 | — | — | CN | claimed |
| EP-2970267-B3 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-30 | — | — | EP | claimed |
| US-9783537-B2 | 3-(4-ethylnylphenyl) pyridopyrimidinone compounds and process for preparation thereof useful as potential anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-10-10 | — | — | US | claimed |
| US-20160222006-A1 | 3-(4-Ethylnylphenyl) Pyridopyrimidinone Compounds and Process for Preparation Thereof Useful As Potential Anticancer Agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-08-04 | — | — | US | claimed |
| CN-105209464-A | P2x7 modulators | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | claimed |
| WO-2015025326-A1 | 3-(4-ETHYNYLPHENYL) PYRIDOPYRIMIDINONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF USEFUL AS POTENTIAL ANTIC ANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-26 | — | — | WO | claimed |
| CN-102149379-A | Methods of modulating hepatocyte growth factor (scatter factor) activity and small molecule modulator compositions of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP | 2011-08-10 | — | — | CN | claimed |
| US-20070219266-A1 | N-Acylated-3-(Benzoyl)-Pyrrolidines as 11-Beta-HSD1 Inhibitors Useful for the Treatment of Metabolic Disorders | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | US | claimed |
| US-20070112000-A1 | Chemical compounds | ASTRAZENECA R&D ALDERLEY (GB) | 2007-05-17 | — | — | US | claimed |
| EP-1684757-A1 | SUBSTITUTED PIPERIDINES FOR THE TREATMENT OF METABOLIC SYNDROME | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| EP-1685101-A1 | N-ACYLATED-3-(BENZOYL)-PYRROLIDINES AS 11-BETA-HSD1 INHIBITORS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS. | AstraZeneca AB (SE) | 2006-08-02 | — | — | EP | claimed |
| US-20060084176-A1 | Detection of uronium salts | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2006-04-20 | — | — | US | claimed |
| WO-2005046685-A1 | SUBSTITUTED PIPERIDINES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2005-05-26 | — | — | WO | claimed |
| WO-2005047250-A1 | N-ACYLATED-3- (BENZOYL) - PYRROLIDINES AS 11-BETA-HSD1 INHIBITORS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS. | ASTRAZENECA AB (SE) | 2005-05-26 | — | — | WO | claimed |
| US-20040132807-A1 | Aurones as telomerase inhibitors | PHARMACIA ITALIA SPA (IT) | 2004-07-08 | — | — | US | claimed |
| CN-1076448-A | Novel herbicide | R P AGRICULTURE LTD (GB) | 1993-09-22 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219266-A1 | N-Acylated-3-(Benzoyl)-Pyrrolidines as 11-Beta-HSD1 Inhibitors Useful for the Treatment of Metabolic Disorders | HSD11B1, HSD3B1, HSD17B1 | PIM1 2682/4885PIM2 3792/4885SRC 4545/4885 |
| US-20070112000-A1 | Chemical compounds | HSD11B1, CYP11B1, HSD11B2 | PIM1 4336/4885PIM2 4769/4885SRC 4132/4885 |
| US-20160222006-A1 | 3-(4-Ethylnylphenyl) Pyridopyrimidinone Compounds and Process for Preparation Thereof Useful As Potential Anticancer Agents | CBR3, HCCS, CYP3A4 | PIM1 439/4885PIM2 322/4885SRC 2965/4885 |
| US-20040132807-A1 | Aurones as telomerase inhibitors | TERT, TERF2, TERF2IP | PIM1 555/4885PIM2 1095/4885SRC 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.