Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873257 | 1.00 | HSD11B1 (0.58) | HSD11B1MCHR1RAB9AADRA2AALDH1A1 | |
| SCHEMBL6866386 | 0.93 | HSD11B1 (0.48) | HSD11B1MCHR1RAB9AADRA2AALDH1A1 | |
| SCHEMBL6866381 | 0.93 | HSD11B1 (0.48) | HSD11B1MCHR1RAB9AADRA2AALDH1A1 | |
| SCHEMBL6868859 | 0.91 | HSD11B1 (0.47) | HSD11B1MCHR1ADRA2A | |
| SCHEMBL6878491 | 0.90 | RAB9A (0.56) | MCHR1RAB9AADRA2AALDH1A1MEN1 | |
| SCHEMBL6878501 | 0.90 | RAB9A (0.56) | MCHR1RAB9AADRA2AALDH1A1MEN1 | |
| SCHEMBL6874188 | 0.87 | ALDH1A1 (0.58) | MCHR1RAB9AADRA2AALDH1A1KMT2A | |
| SCHEMBL6874182 | 0.87 | ALDH1A1 (0.58) | MCHR1RAB9AADRA2AALDH1A1KMT2A | |
| SCHEMBL13792794 | 0.85 | MCHR1 (0.66) | HSD11B1MCHR1RAB9AADRA2A | |
| SCHEMBL6877359 | 0.84 | MCHR1 (0.45) | HSD11B1MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |