Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 11/20 | 0.63 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686453 | 0.84 | ILK (0.70) | ILKAHR | |
| SCHEMBL6234898 | 0.77 | ILK (1.00) | ILK | |
| SCHEMBL687684 | 0.73 | ILK (0.70) | ILKAPP | |
| SCHEMBL10706363 | 0.71 | APP (0.68) | ILKAHRDYRK1AAPP | |
| SCHEMBL1319670 | 0.69 | SMN1; SMN2 (0.57) | ILKAHRDYRK1A | |
| SCHEMBL30421999 | 0.69 | SMN1; SMN2 (0.57) | ILKAHRDYRK1A | |
| SCHEMBL686809 | 0.68 | ILK (0.72) | ILKDYRK1A | |
| SCHEMBL686934 | 0.68 | ILK (0.70) | ILKAPP | |
| SCHEMBL27897630 | 0.67 | AHR (0.58) | AHRDYRK1AAPP | |
| SCHEMBL686711 | 0.67 | ILK (1.00) | ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | disclosed |