Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 13/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876384 | 1.00 | MCHR1 (0.45) | MCHR1ADRA2AL3MBTL1GAAACHE | |
| SCHEMBL6867789 | 0.87 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL28759293 | 0.87 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL6872140 | 0.86 | MCHR1 (0.41) | MCHR1ADRA2AACHENPY5RHTR1A | |
| SCHEMBL6872137 | 0.86 | MCHR1 (0.41) | MCHR1ADRA2AACHENPY5RHTR1A | |
| SCHEMBL6877262 | 0.86 | ADRA2A (0.48) | MCHR1ADRA2AACHENPY5R | |
| SCHEMBL6460350 | 0.86 | ADRA2A (0.48) | MCHR1ADRA2AACHENPY5R | |
| SCHEMBL6467595 | 0.85 | LMNA (0.53) | MCHR1ADRA2AACHEHTR1A | |
| SCHEMBL6875174 | 0.85 | LMNA (0.53) | MCHR1ADRA2AACHEHTR1A | |
| SCHEMBL6456933 | 0.83 | MCHR1 (0.46) | MCHR1ADRA2AL3MBTL1GAANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |