Sugi Predict

Sugi Predict / Compounds / SCHEMBL6879657

SCHEMBL6879657

SCHEMBL6879657

C=C(C(=O)OCC)c1csc(-c2ccc(OC)c(C(C)(C)C)c2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RARA P10276 2/20 0.44
▸ RARB P10826 2/20 0.44
▸ RARG P13631 2/20 0.44
▸ TNFRSF1A P19438 4/20 0.40
▸ PRKCZ Q05513 1/20 0.36
▸ HTT P42858 1/20 0.35
▸ MAPT P10636 4/20 0.35
▸ ATM Q13315 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ HCRTR1 O43613 1/20 0.34
▸ HCRTR2 O43614 1/20 0.34
▸ GAA P10253 2/20 0.34
▸ TUBB4A P04350 1/20 0.34
▸ TUBB P07437 1/20 0.34
▸ TUBA3C P0DPH7 1/20 0.34
▸ TUBA1B P68363 1/20 0.34
▸ TUBA4A P68366 1/20 0.34
▸ TUBB4B P68371 1/20 0.34
▸ TUBB3 Q13509 1/20 0.34
▸ TUBB2A Q13885 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6871319 0.86 RARA (0.47) RARARARBRARGTNFRSF1APRKCZ
SCHEMBL6878042 0.85 RARA (0.51) RARARARBRARGTNFRSF1AATM
SCHEMBL7024749 0.80 RARB (0.62) RARARARBRARGTNFRSF1AHTT
SCHEMBL6879655 0.75 FDPS (0.50) RARARARBRARGTNFRSF1AMAPT
SCHEMBL6879653 0.75 FDPS (0.50) RARARARBRARGTNFRSF1AMAPT
SCHEMBL6880780 0.71 RARA (0.44) RARARARBRARGTNFRSF1AGAA
SCHEMBL6877457 0.71 RARB (0.53) RARARARBRARGMAPTATM
SCHEMBL9765714 0.70 MAPK1 (0.55) HTTMAPTGAAMEN1KMT2A
SCHEMBL19639412 0.70 PDGFRB (0.48) RARARARBRARGTNFRSF1AHTT
SCHEMBL6879410 0.70 FDPS (0.46) RARARARBRARGTNFRSF1APRKCZ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825360-B1 Bicyclic aromatic compounds GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-11-30 — — US disclosed
US-20030135053-A1 For use in human or veterinary conditions, that may be dermatological, rheumatic, respiratory, or cardiovascular and may be used in cosmetics BERNARDON JEAN-MICHEL 2003-07-17 — — US disclosed
US-20030060491-A1 Bicyclic aromatic compounds BERNARDON JEAN-MICHEL (FR) 2003-03-27 — — US disclosed
US-6515021-B1 Bicyclic aromatic compounds CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2003-02-04 — — US disclosed
US-6147255-A TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL COMPLAINTS ASSOCIATED WITH KERATINIZATION DISORDER WHICH HAS EFFECT ON DIFFERENTIATION AND ON PROLIFERATION CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-11-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030060491-A1 Bicyclic aromatic compounds MITF, TYR, PAH RARA 451/4885RARB 529/4885RARG 474/4885
US-20030135053-A1 For use in human or veterinary conditions, that may be dermatological, rheumatic, respiratory, or cardiovascular and may be used in cosmetics MITF, TYR, PAH RARA 52/4885RARB 93/4885RARG 69/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.