Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886930 | 0.87 | KDM4E (0.38) | SMN1; SMN2KDM4EGMNNLMNAMAPT | |
| SCHEMBL6885470 | 0.86 | KDM4E (0.32) | SMN1; SMN2KDM4EGMNNLMNAMAPT | |
| SCHEMBL6889023 | 0.77 | LMNA (0.36) | SMN1; SMN2KDM4EGMNNLMNAMAPT | |
| SCHEMBL6886952 | 0.72 | ACHE (0.33) | SMN1; SMN2KDM4EGMNNLMNAMAPT | |
| SCHEMBL6887365 | 0.72 | TP53 (0.35) | SMN1; SMN2TP53HSD17B10 | |
| SCHEMBL6881897 | 0.71 | ALDH1A1 (0.32) | — | |
| SCHEMBL6945387 | 0.71 | ADORA2A (0.35) | SMN1; SMN2TP53ADKHSD17B10 | |
| SCHEMBL11442293 | 0.69 | KDM4E (0.47) | SMN1; SMN2KDM4EGMNNLMNAMAPT | |
| SCHEMBL6887345 | 0.69 | KDM4E (0.45) | SMN1; SMN2KDM4EGMNNLMNAMAPT | |
| SCHEMBL6880484 | 0.69 | TP53 (0.64) | SMN1; SMN2STAT6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |