Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689128 | 0.80 | MAPT (0.37) | TP53HTTALDH1A1KMT2APKM | |
| SCHEMBL689301 | 0.79 | PTPRC (0.34) | TP53HTTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL688883 | 0.79 | KEAP1 (0.38) | ALDH1A1KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL15486114 | 0.78 | ALDH1A1 (0.74) | TP53HTTALDH1A1KMT2ARAB9A | |
| SCHEMBL3149715 | 0.72 | HTT (1.00) | TP53HTTALDH1A1KMT2ARAB9A | |
| SCHEMBL6398309 | 0.70 | KMT2A (0.71) | ALDH1A1KMT2ARAB9APKMSMN1; SMN2 | |
| SCHEMBL28405139 | 0.70 | KMT2A (0.57) | TP53HTTALDH1A1KMT2ARAB9A | |
| SCHEMBL3955084 | 0.70 | KMT2A (0.61) | TP53HTTALDH1A1KMT2ARAB9A | |
| SCHEMBL11153565 | 0.70 | HTT (0.51) | TP53HTTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4437870 | 0.70 | KMT2A (0.60) | HTTALDH1A1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |