Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPRA | P18433 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | PTPRE | P23469 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688778 | 0.84 | CSNK2A1 (0.37) | MAP2K2MAP2K1ALDH1A1GLATSHR | |
| SCHEMBL689128 | 0.84 | MAPT (0.37) | PTPN1ALDH1A1GLATSHRMEN1 | |
| SCHEMBL688883 | 0.83 | KEAP1 (0.38) | ALDH1A1GLATSHRMEN1MAPT | |
| SCHEMBL2002664 | 0.70 | PTGDR2 (0.44) | ALDH1A1GLATSHRMAPTHPGD | |
| SCHEMBL688887 | 0.67 | LMNA (0.41) | ALDH1A1GLATSHRMEN1MAPT | |
| SCHEMBL18038517 | 0.66 | MAP2K2 (0.41) | MAP2K2MAP2K1 | |
| SCHEMBL688069 | 0.66 | MAP2K2 (0.46) | PTPRCPTPN2PTPN1PTPRAPTPRB | |
| SCHEMBL689046 | 0.66 | RORC (0.40) | ALDH1A1GLATSHRMAPT | |
| SCHEMBL31373249 | 0.65 | MAP2K2 (0.41) | PTPRCPTPN2PTPN1PTPRAPTPRB | |
| SCHEMBL688068 | 0.65 | MAP2K2 (0.37) | PTPRCPTPN2PTPN1PTPRAPTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |