Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688778 | 0.84 | CSNK2A1 (0.37) | TSHRPARP1MEN1MAPTKMT2A | |
| SCHEMBL689128 | 0.84 | MAPT (0.37) | TSHRMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL689301 | 0.83 | PTPRC (0.34) | TSHRMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL688700 | 0.81 | KDM4E (0.40) | TSHRPARP1MEN1MAPTKMT2A | |
| SCHEMBL31565670 | 0.75 | IKBKB (0.49) | KEAP1TSHRCES2CES1PARP1 | |
| SCHEMBL689046 | 0.71 | RORC (0.40) | TSHRCES2CES1MAPTALDH1A1 | |
| SCHEMBL12023001 | 0.71 | MAPK8 (0.46) | KEAP1CES2CES1PARP1MEN1 | |
| SCHEMBL2002664 | 0.70 | PTGDR2 (0.44) | TSHRCES2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10209769 | 0.67 | LMNA (0.47) | KEAP1CES2CES1PARP1MEN1 | |
| SCHEMBL688887 | 0.67 | LMNA (0.41) | TSHRMEN1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |