Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MGLL | Q99685 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842397 | 0.89 | MGLL (0.58) | MAPTALDH1A1KDM4EMGLLTP53 | |
| SCHEMBL2293225 | 0.89 | MGLL (0.60) | MAPTALDH1A1MGLLTP53ATM | |
| SCHEMBL7321919 | 0.88 | EGFR (0.57) | MAPTALDH1A1KDM4EMGLLTP53 | |
| SCHEMBL9147173 | 0.88 | MAPT (0.53) | MAPTALDH1A1KDM4EMGLLATM | |
| SCHEMBL9149313 | 0.88 | ALDH1A1 (0.53) | MAPTALDH1A1KDM4EMGLLTP53 | |
| SCHEMBL8748204 | 0.88 | MGLL (0.59) | MAPTALDH1A1MGLLTP53ATM | |
| SCHEMBL9149961 | 0.86 | MGLL (0.62) | MAPTALDH1A1KDM4EMGLLATM | |
| SCHEMBL15388302 | 0.85 | MGLL (0.59) | MAPTALDH1A1MGLLTP53ATM | |
| SCHEMBL12892589 | 0.83 | MGLL (0.60) | MAPTALDH1A1MGLLTP53ATM | |
| SCHEMBL3175561 | 0.83 | MGLL (0.60) | MAPTALDH1A1MGLLTP53ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1211375-C | Thiazole-derivaties | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | CN | disclosed |
| EP-1123283-B1 | THIAZOLE-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-05-06 | — | — | EP | disclosed |
| EP-0928790-B1 | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2003-03-05 | — | — | EP | disclosed |
| CN-1359381-A | Thiazole-derivaties | HOFFMANN LA ROCHE (CH) | 2002-07-17 | — | — | CN | disclosed |
| US-6358960-B1 | FOR THERAPY OF INTRAVASCULAR COAGULATION, CORONARY THROMBOSIS, CEREBRAL INFARCTION, CEREBRAL EMBOLISM, TRANSIENT ISCHEMIC ATTACK, CEREBROVASCULAR DISORDERS, PULMONARY VASCULAR DISEASES, DEEP VENOUS THROMBOSIS, ETC. | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6344562-B1 | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2002-02-05 | — | — | US | disclosed |
| US-20020010316-A1 | Thiazole derivatives | ALIG LEO (CH) | 2002-01-24 | — | — | US | disclosed |
| US-6320054-B1 | INHIBIT BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES F CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. | HOFFMAN-LA ROCHE INC. | 2001-11-20 | — | — | US | disclosed |
| US-6297266-B1 | INHIBIT THE BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES OF CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. | HOFFMANN-LA ROCHE INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1123283-A1 | THIAZOLE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| US-5466655-A | STORAGE STABILITY | MITSUBISHI PAPER MILLS LIMITED (JP) | 1995-11-14 | — | — | US | disclosed |
| EP-0675002-A1 | Heat-sensitive recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1995-10-04 | — | — | EP | disclosed |
| US-5424292-A | 5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases | DEPHA TEAM S.R.L. (IT) | 1995-06-13 | — | — | US | disclosed |
| EP-0630758-A2 | Heat-sensitive recording material | MITSUBISHI PAPER MILLS, LTD. (JP) | 1994-12-28 | — | — | EP | disclosed |
| EP-0548177-B1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM SRL (IT) | 1994-05-18 | — | — | EP | disclosed |
| US-5306688-A | Color-forming, electron donating compound and electron accepting compound; storage stability of uncolored portion | MITSUI TOATSU CHEMICALS, INC. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0548177-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES. | DEPHA TEAM SRL (IT) | 1993-06-30 | — | — | EP | disclosed |
| EP-0534257-A1 | Salicylic acid derivatives, the process for preparing the same and the heat-sensitive recording materials comprising thereof | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1993-03-31 | — | — | EP | disclosed |
| WO-1992004369-A1 | 5-AMINOSALICYLIC ACID DERIVATIVES FOR THE THERAPY OF CHRONIC INFLAMMATORY BOWEL DISEASES | DEPHA TEAM S.R.L. (IT) | 1992-03-19 | — | — | WO | disclosed |
| US-4146631-A | ANTIALLERGENS, RESPIRATORY DISORDERS | MAY & BAKER LIMITED (GB) | 1979-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010316-A1 | Thiazole derivatives | VCAM1, SOST, TGFB1 | MAPT 86/4885ALDH1A1 1400/4885KDM4E 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.