Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.48 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31312276 | 0.86 | ACMSD (0.70) | ACMSDPTGER1ERCC5FEN1GRIK1 | |
| SCHEMBL31312075 | 0.83 | CYP4F2 (0.59) | ERCC5FEN1MEN1KMT2AALDH1A1 | |
| SCHEMBL787287 | 0.83 | CYP4F2 (0.59) | ERCC5FEN1MEN1KMT2AALDH1A1 | |
| SCHEMBL30402090 | 0.82 | CYP4F2 (0.61) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL844419 | 0.82 | CYP4F2 (0.61) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL122520 | 0.80 | ACMSD (0.63) | ACMSDPTGER1ERCC5FEN1GRIK1 | |
| SCHEMBL2771204 | 0.80 | ALDH1A1 (0.68) | ACMSDPTGER1ERCC5FEN1GRIK1 | |
| SCHEMBL15936129 | 0.79 | ALDH1A1 (0.63) | ACMSDERCC5FEN1GRIK1GRIA1 | |
| SCHEMBL31312218 | 0.78 | RXRA (0.62) | ACMSDERCC5FEN1GRIK1GRIA1 | |
| SCHEMBL14783994 | 0.76 | DCLRE1B (0.57) | ACMSDERCC5FEN1GRIK1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011116356-A2 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-22 | — | — | WO | disclosed |