Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.54 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122520 | 0.87 | ACMSD (0.63) | ALDH1A1TP53DCLRE1BGRIK1GRIA1 | |
| SCHEMBL2771204 | 0.87 | ALDH1A1 (0.68) | ALDH1A1TP53GRIK1GRIA1GRIA2 | |
| SCHEMBL31312218 | 0.84 | RXRA (0.62) | ALDH1A1TP53GRIK1GRIA1GRIA2 | |
| SCHEMBL10024258 | 0.83 | DCLRE1B (0.57) | DCLRE1BACMSDRXRARXRBALOX5 | |
| SCHEMBL14783994 | 0.83 | DCLRE1B (0.57) | ALDH1A1TP53DCLRE1BGRIK1GRIA1 | |
| SCHEMBL787118 | 0.83 | AKR1C2 (0.70) | ALDH1A1TP53GRIK1GRIA1GRIA2 | |
| SCHEMBL28694686 | 0.81 | DCLRE1B (0.56) | DCLRE1BGRIK1ACMSDAKR1C2AKR1C1 | |
| SCHEMBL786961 | 0.80 | MGLL (0.56) | ALDH1A1TP53DCLRE1BGRIK1GRIA1 | |
| SCHEMBL2560594 | 0.80 | TRIM24 (0.62) | ALDH1A1TP53GRIK1GRIA1GRIA2 | |
| SCHEMBL31312276 | 0.80 | ACMSD (0.70) | ALDH1A1TP53GRIK1GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953927-B1 | SUBSTITUTED BENZAMIDES WITH ACTIVITY TOWARDS EP4 RECEPTORS | DRACONIS PHARMA S L (ES) | 2016-11-16 | — | — | EP | disclosed |
| EP-2765128-A1 | Substituted benzamides with activity towards EP4 receptors | Almirall, S.A. (ES) | 2014-08-13 | — | — | EP | disclosed |