Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6897889 | 0.91 | CNR2 (0.38) | SLC6A2SLC6A4SLC6A3CNR2 | |
| SCHEMBL6896918 | 0.91 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3PTGDR2KDM4E | |
| SCHEMBL6898718 | 0.90 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3PTGDR2KDM4E | |
| SCHEMBL6894708 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3PTGDR2KDM4E | |
| SCHEMBL6777431 | 0.89 | PARP1 (0.41) | PTGDR2F10CYP1A2CYP2A6CNR2 | |
| SCHEMBL6894814 | 0.89 | MAPT (0.44) | KDM4EKMT2AMEN1GAANPSR1 | |
| SCHEMBL6893995 | 0.88 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3KDM4EKMT2A | |
| SCHEMBL6896777 | 0.87 | FAAH (0.44) | KDM4EKMT2AMEN1GAA | |
| SCHEMBL6896536 | 0.86 | MAPK8 (0.47) | KDM4EKMT2AF10MEN1MAPK8 | |
| SCHEMBL6897434 | 0.86 | MAPT (0.39) | KDM4EKMT2AF10MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |