Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694748 | 0.90 | MAPT (0.43) | THRBKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL6896918 | 0.89 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3KMT2AKDM4E | |
| SCHEMBL6778086 | 0.88 | F10 (0.40) | THRATHRBF10 | |
| SCHEMBL6898718 | 0.88 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3KMT2AKDM4E | |
| SCHEMBL6889596 | 0.88 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3KMT2AKDM4E | |
| SCHEMBL6892310 | 0.88 | FAAH (0.41) | THRBALDH1A1 | |
| SCHEMBL6894722 | 0.88 | PLA2G2A (0.41) | THRATHRBALDH1A1MAPK8 | |
| SCHEMBL6890656 | 0.88 | THRB (0.37) | THRATHRBALDH1A1F10 | |
| SCHEMBL6894708 | 0.87 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KMT2AKDM4E | |
| SCHEMBL6895041 | 0.87 | MAPT (0.45) | THRATHRBKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |