Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.36 |
| ▸ | ITGAL | P20701 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688887 | 0.84 | LMNA (0.41) | TSHRALDH1A1GLAMAPT | |
| SCHEMBL10589172 | 0.75 | CES2 (0.47) | RORCTSHRTDP1CES2CES1 | |
| SCHEMBL2754177 | 0.74 | TP53 (0.41) | TSHRTDP1ALDH1A1GLAMAPT | |
| SCHEMBL24239764 | 0.73 | CES2 (0.45) | RORCTDP1CES2CES1ITGB2 | |
| SCHEMBL688883 | 0.71 | KEAP1 (0.38) | TSHRCES2CES1ALDH1A1GLA | |
| SCHEMBL4294748 | 0.70 | TSHR (0.43) | TSHRTDP1ALDH1A1GLAMAPT | |
| SCHEMBL203321 | 0.70 | CES2 (0.64) | TDP1CES2CES1ITGB2ICAM1 | |
| SCHEMBL14731241 | 0.70 | CES2 (0.48) | RORCTDP1CES2CES1ITGB2 | |
| SCHEMBL20550632 | 0.69 | TSHR (0.42) | TSHRTDP1CES2CES1ALDH1A1 | |
| SCHEMBL17078095 | 0.68 | TSHR (0.48) | TSHRTDP1ALDH1A1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |