Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689046 | 0.84 | RORC (0.40) | TSHRALDH1A1GLAMAPT | |
| SCHEMBL2754185 | 0.73 | CYP3A4 (0.58) | LMNACYP3A4TSHRALDH1A1GLA | |
| SCHEMBL311565 | 0.71 | PARP1 (0.46) | CYP3A4TSHRALDH1A1KDM4EMAPT | |
| SCHEMBL688778 | 0.71 | CSNK2A1 (0.37) | TSHRALDH1A1GLAMAPTMEN1 | |
| SCHEMBL2857937 | 0.69 | GABRA1 (0.45) | CYP3A4ALDH1A1SCN5AMEN1KMT2A | |
| SCHEMBL14330473 | 0.68 | L3MBTL1 (0.45) | LMNACYP3A4TSHRALDH1A1TRPM8 | |
| SCHEMBL689128 | 0.68 | MAPT (0.37) | CYP3A4TSHRALDH1A1GLAKDM4E | |
| SCHEMBL7653267 | 0.67 | CYP3A4 (0.63) | LMNACYP3A4TSHRALDH1A1GLA | |
| SCHEMBL689301 | 0.67 | PTPRC (0.34) | TSHRALDH1A1GLAMAPTMEN1 | |
| SCHEMBL688883 | 0.67 | KEAP1 (0.38) | TSHRALDH1A1GLAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7915267-B2 | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-03-29 | — | — | US | disclosed |