Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CD74 | P04233 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771899 | 0.90 | CTNNB1 (0.43) | PTGDR2 | |
| SCHEMBL6895266 | 0.90 | TSPO (0.42) | TSPOKDM4EHSD17B10PTGDR2RAB9A | |
| SCHEMBL6888939 | 0.90 | TSPO (0.42) | TSPOKDM4EHSD17B10RAB9AMEN1 | |
| SCHEMBL6889316 | 0.90 | TSPO (0.47) | TSPOKDM4EHSD17B10PTGDR2RAB9A | |
| SCHEMBL6899176 | 0.88 | TSPO (0.41) | TSPOKDM4EHSD17B10RAB9AMEN1 | |
| SCHEMBL6896220 | 0.86 | FAAH (0.43) | KDM4EMEN1KMT2AGAALMNA | |
| SCHEMBL6893122 | 0.86 | CCR8 (0.40) | TSPOPTGDR2KMT2AGAATDP1 | |
| SCHEMBL6892544 | 0.86 | MAPT (0.44) | KDM4EHSD17B10MEN1KMT2AGAA | |
| SCHEMBL6888714 | 0.86 | TSPO (0.39) | TSPOLMNAMAPT | |
| SCHEMBL6689196 | 0.85 | GAA (0.47) | KDM4EMEN1KMT2AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |