Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | YWHAH | Q04917 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772343 | 0.91 | CTNNB1 (0.40) | — | |
| SCHEMBL6888939 | 0.88 | TSPO (0.42) | TSPOKDM4EHSD17B10RAB9ALMNA | |
| SCHEMBL6895266 | 0.88 | TSPO (0.42) | TSPOKDM4EHSD17B10RAB9ALMNA | |
| SCHEMBL6891056 | 0.88 | TSPO (0.42) | TSPOKDM4EHSD17B10RAB9ALMNA | |
| SCHEMBL6889316 | 0.88 | TSPO (0.47) | TSPOKDM4EHSD17B10ALDH1A1RAB9A | |
| SCHEMBL6892310 | 0.87 | FAAH (0.41) | YWHAHALDH1A1MAPT | |
| SCHEMBL6894947 | 0.86 | MAPT (0.41) | KDM4EHSD17B10ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL6694748 | 0.86 | MAPT (0.43) | KDM4EYWHAHALDH1A1MEN1KMT2A | |
| SCHEMBL6896741 | 0.85 | PLA2G2A (0.41) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6896161 | 0.85 | HSP90AA1 (0.40) | YWHAHALDH1A1L3MBTL1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |