Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK7 | P50613 | 2/20 | 0.31 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238822 | 0.85 | CRHR1 (0.34) | CRHR1CDK9CDK2CDK7CDK13 | |
| SCHEMBL6891477 | 0.84 | — | — | |
| SCHEMBL1083234 | 0.78 | DGAT1 (0.38) | CRHR1 | |
| SCHEMBL6891144 | 0.78 | DGAT1 (0.36) | — | |
| SCHEMBL584995 | 0.77 | KDM4E (0.38) | — | |
| SCHEMBL7874289 | 0.75 | PDE10A (0.36) | CRHR1CDK9CDK2CDK7CDK13 | |
| SCHEMBL7886481 | 0.73 | CRHR1 (0.35) | CRHR1CDK9CDK2CDK7CDK13 | |
| SCHEMBL600785 | 0.73 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL15026289 | 0.72 | CDK2 (0.38) | CRHR1CDK9CDK2CDK7CDK13 | |
| SCHEMBL15807254 | 0.71 | CDK9 (0.33) | CRHR1CDK9CDK2CDK7CDK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |