Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802988 | 0.90 | CHRM1 (0.64) | CHRM1 | |
| SCHEMBL6891034 | 0.85 | CHRM1 (0.65) | CHRM1 | |
| SCHEMBL6892450 | 0.85 | CHRM1 (0.54) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6891717 | 0.82 | CHRM1 (0.54) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6891544 | 0.81 | CHRM1 (0.47) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL2224496 | 0.81 | GAA (0.55) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6890076 | 0.81 | KCNH2 (0.48) | SMN1; SMN2KDM4EALDH1A1LMNARAB9A | |
| SCHEMBL6893880 | 0.80 | CHRM1 (0.54) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6892513 | 0.79 | CHRM1 (0.64) | CHRM1KDM4ERAB9A | |
| SCHEMBL6891970 | 0.79 | GAA (0.49) | SMN1; SMN2KDM4EALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |